Activation of TRPA1 by Membrane Permeable Local Anesthetics
نویسندگان
چکیده
منابع مشابه
Activation of TRPA1 by membrane permeable local anesthetics
BACKGROUND Low concentrations of local anesthetics (LAs) suppress cellular excitability by inhibiting voltage-gated Na⁺ channels. In contrast, LAs at high concentrations can be excitatory and neurotoxic. We recently demonstrated that LA-evoked activation of sensory neurons is mediated by the capsaicin receptor TRPV1, and, to a lesser extent by the irritant receptor TRPA1. LA-induced activation ...
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ژورنال
عنوان ژورنال: Molecular Pain
سال: 2011
ISSN: 1744-8069,1744-8069
DOI: 10.1186/1744-8069-7-62